Using one-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our research pursuits incorporate:
But how do morality, the dignity with the human being, my encounter of the this means of daily life, stick to in the motion of atoms? A purely naturalistic point of view fails right here; a Christian standpoint, I feel, is a much more acceptable approach to interpret these aspects of fact.’
Multicolor imaging on the bacterial nucleoid and cell division proteins with blue, orange, and near-infrared fluorescent proteins
Considering the fact that 2000, Dekker has shifted the principle focus of his operate to biophysics in which he experiments the Qualities of solitary biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was pushed by his fascination for your impressive performing of Organic molecular structures, together with by the extended-expression point of view that numerous fascinating discoveries could be predicted With this industry.[5] Present lines of analysis in his biophysics group are while in the regions of:[six]
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Experimental stage diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is usually that these elements together make up a residing method. The trick of mentioned everyday living, I believe, lies during the interactions, the interplay of These molecules. The massive query about the origin of daily life remains unanswered. How did we ever evolve from uncomplicated molecules in to the particularly complicated devices we see today? We don't know. I need to operate on these kinds of massive, open up concerns.’
2011, to start with in vitro measurements of transportation across just one biomimetic nuclear pore sophisticated; advancement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
The rotors harness Strength from a nanoscale h2o and ion stream which is generated by a static chemical or electrochemical probable gradient while in the nanopore, that are established by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological problems, suggesting methods to developing Strength-transducing motors at nanoscale interfaces.
There was one issue even though — we did not observe any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule degree, conducting polymers have been essentially not these types of terrific conductors, which was rather disappointing. We Hence broadened our check out to try to discover a lot more promising molecules.
Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim of your pore is highlighted in purple, plus a 3D rendering on the motion of your DNA rod is exhibited.
Quite a few new phenomena had been discovered, and he and his exploration https://www.ceesdekker.net group recognized a leading posture On this field of exploration. Dekker and his study team found new physics of nanotubes and explored the feasibility of molecular electronics. In 1998, they have been the first to create a transistor based on one nanotube molecule.
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2004, discovery of latest physics in translocation of DNA via nanopores; first experimental review of ions conduction in nanofluidic channels; first electrochemistry with particular person single-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initial electrical docking of microtubules on kinesin-coated nanostructures; initial biophysics characterization in the mechanical Qualities of double-stranded RNA; and initially one-molecule examine of DNA translocation by a restriction-modification enzyme.